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Updated: Jan 26, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Catalytic Aerobic Phenol Homo- and Cross-Coupling Reactions with Copper Complexes Bearing Redox-Active Guanidine
Florian Schön1, Elisabeth Kaifer1, Hans-Jörg Himmel1
1Anorganisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Abstract:
Due to their large importance in synthetic chemistry, catalytic C-C coupling reactions of phenols are currently intensively studied. Herein, new copper catalysts for the C-C coupling reaction of phenols using dioxygen as a green oxidizing reagent are reported. By using redox-active guanidine ligands, the activity as well as chemoselectivity in the cross-coupling reaction of non-complementary phenols (between an electron-rich phenol and a less nucleophilic second phenol) is significantly improved. Based on the collected data for several test reactions, a reaction mechanism is proposed.
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