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Updated: Jan 26, 2026

Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes
Published on: February 18, 2020
Hemocompatibility of amyloid and/or brain targeted liposomes
Georgios Pa Michanetzis1, Eleni Markoutsa2,3, Spyridon Mourtas4
1Laboratory of Biomedical Engineering, Department of Mechanical Engineering & Aeronautics, University of Patras, Rio, 26510, Greece.
Abstract:
Targeted liposomes with different combinations of five ligands (for brain/amyloid targeting) were evaluated for hemocompatibility. Results reveal that all liposomes studied, caused minimum hemolysis; targeted liposomes slightly reduced blood coagulation time, but not significantly more than control liposomes; and compliment factors SC5b9 and iC3b increased when compared with the buffer, by most targeted liposomes. However, the specific amounts of both factors were similar with those induced by control liposomes. Thus, the targeted liposomes are unanticipated to cause hypersensitivity problems. Good correlations between vesicle size and produced factor amounts were observed. In conclusion, the current targeted liposomes are not expected to cause serious blood toxicity, if used in vivo.
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