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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis

Milad Azami1, Mohammad Hossein YektaKooshali2, Masoumeh Shohani3

  • 1Student Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Plos One
|April 10, 2019
PubMed
Abstract

Insights

This meta-analysis reveals a high and increasing prevalence and incidence of multiple sclerosis (MS) in Iran. The study highlights the rising trend of MS epidemiology in the country over time.

Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a common neurological disorder and a leading cause of disability.
  • Existing data on MS prevalence and incidence in Iran lacks systematic review and meta-analysis.
  • This study addresses the need for a comprehensive understanding of MS epidemiology in Iran.

Purpose of the Study:

  • To conduct a meta-analysis to determine the prevalence and incidence of multiple sclerosis (MS) in Iran.
  • To systematically review and synthesize existing epidemiological data on MS in Iran.
  • To identify trends in MS prevalence and incidence over time within the Iranian population.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA guidelines.
  • Comprehensive search of eight international and six Persian databases until May 2018.
  • Data analysis using Comprehensive meta-analysis software (ver. 2) and registered in PROSPERO (ID: CRD42018114491).

Main Results:

  • The overall prevalence of MS in Iran was estimated at 29.3/100,000, with higher rates in women (44.8/100,000) than men (16.5/100,000).
  • The incidence of MS in Iran was estimated at 3.4/100,000, also showing a higher rate in women (44.8/100,000) compared to men (16.5/100,000).
  • Meta-regression indicated a significant increase in MS prevalence and incidence over the years (p<0.001).

Conclusions:

  • The meta-analysis provides a general overview of MS epidemiology in Iran.
  • Both the prevalence and incidence of MS in Iran are substantial and show an upward trend.
  • Findings underscore the growing public health concern of multiple sclerosis in Iran.

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