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Updated: Jan 26, 2026

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Published on: October 16, 2017
Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action
Yong Xu1, Yu-Ji Wu1, Pei-Long Sun1
1Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Chemically modifying polysaccharides enhances their structural diversity and bioactivities, offering new pharmaceutical and food applications. This review covers synthesis, characterization, bioactivities, and structure-activity relationships of modified polysaccharides.
Area of Science:
- Biochemistry
- Polymer Chemistry
- Medicinal Chemistry
Background:
- Polysaccharides are crucial biomacromolecules with bioactivities influenced by their structure.
- Chemical modifications significantly increase structural diversity, leading to enhanced or novel bioactivities.
Purpose of the Study:
- To review recent advancements in the chemical modification of polysaccharides.
- To explore synthetic methods, structural characterization, bioactivities, and structure-activity relationships.
- To suggest future research directions and applications in pharmaceutical and food industries.
Main Methods:
- Review of common synthetic methods for polysaccharide chemical modification.
- Analysis of structural characterization techniques for modified polysaccharides.
- Compilation of data on the bioactivities of modified polysaccharides.
Main Results:
- Chemical modification expands polysaccharide structural diversity.
- Modified polysaccharides exhibit enhanced antioxidant, anti-tumor, anticoagulant, and immunoregulatory activities.
- Established structure-activity relationships guide the development of novel derivatives.
Conclusions:
- Chemical modification is a powerful strategy to tailor polysaccharide properties.
- Modified polysaccharides hold significant potential for pharmaceutical and food applications.
- Further research into structure-activity relationships will unlock new therapeutic and industrial uses.
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