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Updated: Jan 26, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Current concepts in curative surgery for diabetic forefoot ulcers
Javier La Fontaine1, Peter A Crisologo2, Lawrence Lavery1
1Department of Plastic and Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Diabetic forefoot ulcers are common and often linked to foot deformities and neuropathy. Surgical correction of persistent deformities is necessary when conservative treatments fail to heal these challenging neuropathic foot ulcers.
Area of Science:
- Podiatry
- Diabetology
- Orthopedic Surgery
Background:
- Diabetic forefoot ulcerations are a prevalent complication, significantly impacting patient mobility and quality of life.
- Key risk factors include biomechanical foot deformities and peripheral neuropathy, necessitating effective management strategies.
- Current management emphasizes local wound care, vascular assessment, and offloading, but recurrence is common if deformities persist.
Purpose of the Study:
- To review evidence-based surgical procedures for correcting foot deformities.
- To identify surgical interventions that promote healing of neuropathic forefoot ulcers.
- To provide guidance on surgical management when conservative measures are insufficient.
Main Methods:
- Systematic review of medical literature focusing on surgical interventions for diabetic forefoot ulcers.
- Analysis of studies reporting outcomes of deformity correction in neuropathic feet.
- Evaluation of evidence supporting specific surgical techniques for ulcer healing and recurrence prevention.
Main Results:
- Surgical correction of uncorrectable foot deformities is often required for ulcer healing.
- Various procedures exist to address specific deformities contributing to ulcer recurrence.
- Evidence supports surgical intervention in select cases where conservative offloading fails.
Conclusions:
- Surgical correction of foot deformities is a critical option for intractable neuropathic forefoot ulcers.
- Appropriate surgical techniques can lead to ulcer healing and reduce recurrence rates.
- A multidisciplinary approach integrating surgical expertise is vital for managing complex diabetic foot complications.
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