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Inflammation01:38

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Structural Joints: Fibrous Joints01:03

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
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Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
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The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
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Biofunctional Nanofibrous Substrate for Local TNF-Capturing as a Strategy to Control Inflammation in Arthritic

Elisa Bacelo1,2, Marta Alves da Silva3,4, Cristina Cunha5,6

  • 13B's Research Group, I3Bs-Research Institute of Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Zona Industrial da Gandra, University of Minho, Barco, 4805-017 Guimarães, Portugal. elisabacelo@live.com.pt.

Nanomaterials (Basel, Switzerland)
|April 11, 2019
PubMed
Summary

This study developed a novel nanofibrous substrate to immobilize TNF-α antibodies for localized rheumatoid arthritis treatment. This approach offers sustained therapeutic benefit and avoids systemic side effects, improving joint management.

Keywords:
TNF-α captureantibody immobilizationelectrospun nanofibershuman articular chondrocytesrheumatoid arthritis

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is an autoimmune joint disease driven by pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α).
  • Current TNF-α inhibitor therapies provide symptom relief but have systemic side effects and limitations.
  • Localized treatment strategies are needed to enhance efficacy and reduce adverse events in RA management.

Purpose of the Study:

  • To develop and evaluate a nanofibrous substrate for localized immobilization of TNF-α antibodies.
  • To assess the sustained TNF-α capture capacity and biocompatibility of the functionalized nanofibrous system.
  • To explore a novel therapeutic approach for managing severe joint inflammation in rheumatoid arthritis.

Main Methods:

  • Activation and functionalization of electrospun nanofibers for antibody immobilization.
  • Immobilization of TNF-α antibodies onto the nanofibrous substrate at a concentration of 6 µg/mL.
  • Evaluation of sustained soluble TNF-α capture over time and assessment of chondrocyte metabolism and activity via cell biology assays.

Main Results:

  • The biofunctionalized nanofibrous substrate demonstrated effective and sustained capture of soluble TNF-α.
  • Experimental results confirmed the system's lack of deleterious effects on human articular chondrocytes.
  • The immobilized antibody maintained therapeutic efficacy and prolonged benefit through localized action.

Conclusions:

  • The developed TNF-α-capturing nanofibrous system shows potential for localized RA treatment.
  • This localized approach effectively targets pro-inflammatory cytokines, minimizing systemic side effects.
  • The system offers a promising therapeutic strategy for managing severely affected joints in rheumatoid arthritis patients.