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Methods to Test Endocrine Disruption in Drosophila melanogaster
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Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish.

Sergio Jarque1, Jone Ibarra2, Maria Rubio-Brotons3

  • 1ZeClinics SL, Carretera de Can Ruti, Camí de les Escoles, s/n, Edificio IGTP Muntanya, Badalona, 08916 Barcelona, Spain. sergio.jarque@zeclinics.com.

International Journal of Molecular Sciences
|April 11, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a standardized zebrafish assay using eight gene biomarkers to screen endocrine-disrupting chemicals. This novel method provides a simple, fast, and robust approach for assessing estrogen, androgen, and thyroid disruption.

Keywords:
androgensendocrine disruptionestrogensthyroidtranscriptomicszebrafish

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Area of Science:

  • Environmental Toxicology
  • Molecular Biology
  • Endocrinology

Background:

  • Standardized fish-based assays for endocrine disruption are lacking, hindering reliable chemical screening.
  • Current methods require extensive batteries of tests and vary by species and endocrine pathway.
  • A need exists for a simplified, robust, and rapid assay for endocrine-disrupting compound assessment.

Purpose of the Study:

  • To develop a simple, robust, and fast assay for endocrine-disrupting potencies.
  • To evaluate three major endocrine axes: estrogens, androgens, and thyroid.
  • To propose a panel of eight gene expression biomarkers in zebrafish larvae.

Main Methods:

  • Utilized zebrafish larvae as the experimental model.
  • Selected eight gene expression biomarkers targeting estrogen, androgen, and thyroid pathways.
  • Validated biomarkers using natural ligands (17β-estradiol, testosterone, T3) and known endocrine disruptors.
  • Assessed cross-talk effects of tested compounds.

Main Results:

  • Identified specific gene expression biomarkers responsive to estrogen, androgen, and thyroid signaling.
  • Demonstrated the utility of the biomarker panel in detecting endocrine-disrupting compounds.
  • Established a validated assay for assessing endocrine-disrupting potencies in zebrafish.

Conclusions:

  • The proposed panel of eight gene biomarkers offers a standardized, efficient method for screening endocrine disruptors.
  • This zebrafish assay simplifies the assessment of estrogen, androgen, and thyroid disruption.
  • The assay provides a robust tool for environmental toxicology and chemical safety assessment.