Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classifying Matter by Composition03:35

Classifying Matter by Composition

90.0K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.0K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

14.4K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.4K
Layers of the Epidermis01:21

Layers of the Epidermis

8.0K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
8.0K
Composition of Blood01:22

Composition of Blood

11.7K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
11.7K
Composite Bodies00:55

Composite Bodies

1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
Thematic Layering in GIS01:30

Thematic Layering in GIS

342
In the past, planning projects such as schools or public facilities required extensive manual effort to gather and compile data. Information such as property boundaries, soil characteristics, road networks, zoning regulations, and flood zones had to be sourced individually from courthouses, utility providers, and registry offices. Assembling these datasets into a coherent format often took several months, delaying project timelines.The introduction of Geographic Information Systems (GIS)...
342

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct stress-relaxation behaviour of the interlamellar matrix and transition zone in the intervertebral disc.

Journal of the mechanical behavior of biomedical materials·2026
Same author

Identifying predictors of mortality among the hospitalized road traffic injury patients: a retrospective case-control study (2022-2024).

Scientific reports·2026
Same author

Photodynamically active AIE-functionalised casein nanofibers for antibacterial wound management in epidermolysis bullosa.

Journal of materials chemistry. B·2026
Same author

Integrating Structures and Biology: Cellular and Molecular Interactions with Functionally Graded Spinal Cage Designs.

International journal of molecular sciences·2026
Same author

Sustainable Biopolymer Based on Tung Oil and Tung Free Fatty Acids for Hair Tensile Enhancement.

ACS applied bio materials·2026
Same author

High-performance PVDF/borophene-based TENG for energy harvesting and self-sustaining health monitoring in manual treadmill systems.

Nanoscale·2026

Related Experiment Video

Updated: Jan 26, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
06:45

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

853

Cost-Effective Double-Layer Hydrogel Composites for Wound Dressing Applications.

Javad Tavakoli1,2, Samaneh Mirzaei3, Youhong Tang4,5

  • 1Centre for NanoScale Science and Technology, College of Science and Engineering, Flinders University, Tonsley, SA 5042, Australia. javad.tavakoli@flinders.edu.au.

Polymers
|April 11, 2019
PubMed
Summary

This study introduces a novel double-layered poly vinyl alcohol-poly acrylic acid (PVA-PAA) hydrogel, enhancing swelling properties and biocompatibility for biomedical uses. The new hydrogel shows improved adhesion and drug release characteristics.

Keywords:
adhesionbiocompatibilitydouble-layer hydrogelmechanical propertieswound healing

More Related Videos

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

9.2K
Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
06:45

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

853
Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

9.2K
Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.7K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Poly vinyl alcohol-poly acrylic acid (PVA-PAA) composites are utilized in biomedical applications.
  • Incorporating PVA-PAA into double-layer films is challenging due to interfacial binding affecting water uptake.
  • Existing methods face limitations in maintaining PVA's water capacity.

Purpose of the Study:

  • To develop a simple fabrication method for double-layered PVA-PAA hydrogels.
  • To evaluate the biomedical properties of the novel PVA-PAA hydrogel.
  • To investigate the impact of PAA layers on PVA hydrogel characteristics.

Main Methods:

  • Fabrication of a double-layered PVA-PAA hydrogel using a simple method.
  • Evaluation of swelling properties, water vapor permeability, and adhesion force.
  • Assessment of mechanical properties (tensile strength, modulus, elongation at break).
  • Biocompatibility testing and drug (tetracycline) release studies at different pH levels.

Main Results:

  • The PVA-PAA hydrogel exhibited significantly increased swelling properties compared to PVA (p = 0.035).
  • Water vapor permeability decreased significantly (p = 0.04), while adhesion force increased with higher pH or PAA addition (p < 0.04).
  • Mechanical properties remained largely unchanged. Biocompatibility significantly improved after day 7 (p = 0.016).
  • Tetracycline release was higher at pH 8 than at neutral pH.

Conclusions:

  • The developed double-layered PVA-PAA hydrogel offers enhanced swelling and adhesion properties.
  • The hydrogel demonstrates improved biocompatibility and tunable drug release kinetics.
  • This fabrication method minimizes negative impacts on PVA's water uptake, expanding biomedical applications.