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Recyclable Heterogeneous Chitosan Supported Copper Catalyst for Silyl Conjugate Addition to α,β-Unsaturated Acceptors
Lei Zhu1, Bojie Li2, Shan Wang3
1School of Chemistry and Materials Science, Hubei Engineering University, Hubei Collaborative Innovation Center of Conversion and Utilization for Biomass Resources, Xiaogan 432000, China. zhuleio@mail.ustc.edu.cn.
Abstract:
The first example of an environmentally-benign chitosan supported copper catalyzed conjugate silylation of α,β-unsaturated acceptors was accomplished in water under mild conditions. This protocol provides an efficient pathway to achieve an important class of β-silyl carbonyl compounds and the desired products were obtained in good to excellent yields. Gram-scale synthesis and easy transformation of obtained β-silyl products were also been demonstrated. Remarkably, this chitosan supported copper catalyst can be easily recycled and reused six times without any significant decrease of catalytic activity. The advantages of this newly developed method include operational simplicity, good functional group tolerance, scale-up ability, ready availability, and easy recyclability of catalyst.
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