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Reversible pH-Sensitive Chitosan-Based Hydrogels. Influence of Dispersion Composition on Rheological Properties and

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Summary

This study developed novel chitosan (CTS) hydrogels for drug delivery, optimizing composition for controlled release of diclofenac sodium (DCNa). The synthesized biomaterials offer tunable properties for effective drug carrier applications.

Keywords:
DSCMTDSCdrug delivery systemseco-friendly formulationsionic cross-linkingthermal transition sol-gel

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Chitosan (CTS) is a versatile biopolymer with potential for drug delivery applications.
  • Developing micro-structured chitosan hydrogels requires understanding the impact of formulation parameters on properties.
  • Existing research lacks comprehensive studies on chitosan hydrogel composition for drug delivery systems (DDS).

Purpose of the Study:

  • To synthesize and characterize micro-structured chitosan (CTS) hydrogels using tricarballylic acid (TCA) cross-linking.
  • To investigate the influence of CTS concentration, cross-linking degree, and drug loading on hydrogel properties and drug release.
  • To evaluate the potential of these novel hydrogels as biocompatible drug carriers, comparing them to a commercial product.

Main Methods:

  • Hydrogel synthesis via functional cross-linking of chitosan with tricarballylic acid.
  • Characterization using Fourier transform infrared spectroscopy (FT-IR), modulated temperature differential scanning calorimetry (MTDSC), and scanning electron microscopy (SEM).
  • Rheological property assessment and in vitro drug release studies using diclofenac sodium (DCNa) as a model drug.

Main Results:

  • Hydrogel rheological properties varied from liquid-like to viscoelastic gels based on composition (CTS concentration and cross-linking degree).
  • Drug release profiles were highly dependent on formulation, with cumulative release ranging from 8% to 67% over 96 hours.
  • Some synthesized hydrogels exhibited comparable spreadability to Voltaren Emulgel® and demonstrated reproducible batch synthesis.

Conclusions:

  • The study successfully developed tunable chitosan hydrogels for controlled drug delivery.
  • Formulation composition significantly impacts rheological behavior and drug release kinetics.
  • These reproducible chitosan-based systems show promise as effective and biocompatible drug carriers.