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Prokaryotic cells possess a variety of inclusions that play crucial roles in nutrient storage, metabolic processes, and environmental adaptation. These structures enable bacteria to thrive under fluctuating environmental conditions by storing essential resources and optimizing their metabolic efficiency.Carbon Storage: Poly-β-Hydroxybutyric Acid and Glycogen GranulesBacteria frequently store excess carbon in specialized granules. Poly-β-hydroxybutyric acid (PHB) granules are lipid...
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Related Experiment Video

Updated: Jan 26, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes.

Ganesh Narayanan1, Jialong Shen2, Ramiz Boy3

  • 1Fiber and Polymer Science Program, North Carolina State University, Raleigh, NC 27695, USA. gnaraya@ncsu.edu.

Polymers
|April 11, 2019
PubMed
Summary
This summary is machine-generated.

Polymeric nanofibers functionalized with cyclodextrins (CDs) and their inclusion complexes (ICs) offer advanced molecular capture and controlled delivery. Novel polypseudorotaxane (PpR) nanofibers exhibit unique properties for biomedical applications, including tissue engineering.

Keywords:
controlled drug deliverycyclodextrin-inclusion complexescyclodextrinsmechanical propertiespoly(lactic acid)poly(ε-caprolactone)pseudorotaxanesrapid dissolution

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Electrospinning is a popular method for fabricating nanofibers.
  • Recent advancements involve functionalizing polymeric nanofibers with cyclodextrins (CDs) and their inclusion complexes (ICs).
  • These functionalized nanofibers have potential applications in molecular capture and controlled delivery.

Purpose of the Study:

  • To explore the fabrication and properties of polymeric nanofibers functionalized with CDs and CD-ICs.
  • To investigate the potential of these nanofibers for molecular capture, controlled delivery, and improved thermomechanical properties.
  • To report on the development of novel polypseudorotaxane (PpR) nanofibers and their suitability for biomedical applications.

Main Methods:

  • Fabrication of nanofibers via electrospinning.
  • Functionalization of nanofibers using free CDs and CD-ICs.
  • Characterization of thermomechanical and rheological properties.
  • Exploration of core-shell and multilayered structures for controlled delivery.
  • Bioconjugation strategies for enhanced functionality.

Main Results:

  • Polymeric nanofibers with free CDs can capture small molecules like odors and toxins.
  • Combining polymers with CD-ICs allows for enhanced or controlled delivery of small molecules.
  • Non-stoichiometric inclusion complexes significantly improve the thermomechanical properties of polymeric nanofibers.
  • Novel polypseudorotaxane (PpR) nanofibers exhibit unusual rheological and thermomechanical properties.
  • PpR nanofibers possess surface hydroxyl groups suitable for bioconjugation, indicating potential in biomedical applications, particularly bone tissue engineering.

Conclusions:

  • Functionalized nanofibers offer versatile platforms for molecular capture and controlled release.
  • PpR nanofibers represent a promising new class of materials with unique properties for advanced applications.
  • Further research into bioconjugation of these nanofibers can unlock broader biomedical potential, including tissue engineering.