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Trithiocarbonate-Functionalized PNiPAAm-Based Nanocomposites for Antimicrobial Properties.

Milène Tan1, Lenke Horvàth2, Priscilla S Brunetto3

  • 1Department of Chemistry, University of Fribourg, Chemin du Musée, 9, 1700 Fribourg, Switzerland. milene.tan@unifr.ch.

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|April 11, 2019
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Summary

This study synthesized polymer-silver nanocomposites with thermoresponsive properties. These materials demonstrated antimicrobial activity against E. coli and S. aureus, with silver release influenced by nanoparticle size and polymer length.

Keywords:
antimicrobialnanocompositespoly(N-isopropylacrylamide)silver

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Area of Science:

  • Polymer Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Thermoresponsive polymers like Poly(N-isopropylacrylamide) (PNiPAAm) offer tunable properties.
  • Silver nanoparticles (AgNPs) are known for their antimicrobial efficacy.
  • Combining polymers and AgNPs can create advanced functional materials.

Purpose of the Study:

  • To synthesize and characterize trithiocarbonate-functionalized PNiPAAm/AgNP nanocomposites.
  • To investigate the influence of polymer molecular weight and silver loading on nanocomposite properties.
  • To evaluate the thermoresponsive behavior, silver ion release kinetics, and antimicrobial activity of the developed nanocomposites.

Main Methods:

  • Synthesis of four trithiocarbonate-functionalized PNiPAAm polymers with varying molecular weights.
  • Preparation of polymer-to-silver nanoparticle composites (PNiPAAm/AgNP) at different ratios.
  • UV-Vis spectroscopy to assess thermoresponsive behavior and thermo-reversibility.
  • Release kinetics studies to quantify silver ion release.
  • Antimicrobial testing against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

Main Results:

  • The synthesized PNiPAAm/AgNP nanocomposites exhibited thermoresponsive behavior and thermo-reversibility.
  • Silver ion release kinetics were found to be primarily dependent on the size of AgNPs, which is influenced by polymer chain length.
  • Several nanocomposite formulations demonstrated significant antimicrobial activity, with some achieving complete bacterial killing against both E. coli and S. aureus.

Conclusions:

  • Trithiocarbonate-functionalized PNiPAAm can serve as an effective matrix for creating thermoresponsive silver nanocomposites.
  • The molecular weight of the polymer plays a crucial role in determining AgNP size and subsequent silver ion release.
  • The developed PNiPAAm/AgNP nanocomposites show promise as antimicrobial agents for various applications.