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Updated: Aug 13, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Treatment of pulmonary hypertension with transdermal nitroglycerin
Abstract:
Glycerol trinitrate in patches (DEPONIT 10) resulted in a statistically significant pressure drop in the pulmonary artery, the pulmonary capillaries, and the right atrium within 24 hours following drug application. This pressure reduction was recorded also after 4 weeks of continuous therapy. The reduction of pulmonary artery pressure and pulmonary vascular resistance is not only a consequence of improved pre- and afterload, but in addition also of a decrease in airways resistance and direct influence on arteriolar constriction in the pulmonary vascular bed. The beneficial effects upon pulmonary haemodynamics were equally recorded several months later.
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