Related Experiment Video

Updated: Jan 26, 2026

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
09:10

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

Published on: January 20, 2010

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Post-transplant lymphoproliferative disease of the larynx

Nathan D Vandjelovic1,2, Patrick C Barth1,2,3, Stephen P Dunn3,4

  • 1Division of Pediatric Otolaryngology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Journal of Surgical Case Reports
|April 11, 2019
PubMed

Insights

Laryngeal post-transplant lymphoproliferative disease (PTLD) is rare in children. Reducing immunosuppression effectively treated airway obstruction in two pediatric liver transplant patients with PTLD.

Area of Science:

  • Pediatric medicine
  • Transplant surgery
  • Oncology

Background:

  • Post-transplant lymphoproliferative disease (PTLD) is a rare but serious complication following organ transplantation.
  • Laryngeal PTLD, specifically, presents a diagnostic challenge due to its rarity and potential for airway compromise.

Observation:

  • Two pediatric liver transplant recipients presented with distinct airway obstruction symptoms.
  • Case 1: A 15-month-old with epiglottic and arytenoid infiltrate consistent with polymorphic PTLD.
  • Case 2: A 23-month-old with submucosal infiltrate in the epiglottis, arytenoids, post-cricoid region, and uvula, diagnosed as monomorphic PTLD.

Findings:

  • Both pediatric patients exhibited symptoms of airway obstruction attributed to PTLD.
  • Histopathological examination confirmed polymorphic PTLD in one case and monomorphic PTLD in the other.
  • Successful resolution of airway symptoms and findings was achieved by reducing immunosuppression in both patients.

Implications:

  • This case series highlights the importance of considering laryngeal PTLD in pediatric transplant recipients presenting with airway obstruction.
  • Prompt diagnosis and management, including immunosuppression modulation, are crucial for favorable outcomes.
  • Increased clinical suspicion is warranted for PTLD in any post-transplant patient with unexplained airway compromise.

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