Primary hepatic follicular dendritic cell sarcoma: A case report

Area of Science:

• Oncology
• Pathology

Background:

• Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with no established standard treatment.
• Surgery is the primary treatment, with chemotherapy and radiotherapy as optional adjuncts.
• Metastatic FDCS necessitates multidisciplinary care, but chemotherapy choices remain debated.

Observation:

• A 66-year-old woman with liver cancer was diagnosed with primary hepatic FDCS post-hepatectomy.
• Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) revealed lymph node metastases.
• The patient received gemcitabine and docetaxel chemotherapy due to surgical ineligibility.

Findings:

• Systemic chemotherapy led to significant reduction and clinical complete remission of metastatic lymph nodes.
• Consolidated radiotherapy was administered after chemotherapy.
• The patient achieved disease control and remained progression-free.

Implications:

• This case suggests that a combination regimen of gemcitabine, docetaxel, and radiotherapy may be a promising treatment for metastatic hepatic FDCS.
• Optimizing chemotherapy regimens is crucial for managing this rare tumor.
• Further research into effective treatment strategies for metastatic FDCS is warranted.