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Updated: Jan 26, 2026
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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
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[A suspected carcinoma finding in the uterus]
P Kahl1, J Quakernack2, C Kuhnen3
1Institut für Pathologie am Clemenshospital, Düesbergweg 128, 48153, Münster, Deutschland.
Der Pathologe
|April 11, 2019
Summary
Uterine perivascular epithelioid cell tumors (PEComas) can resemble carcinoma cells in endometrial biopsies. Immunohistochemistry, specifically HMB45 positivity and keratin negativity, is crucial for accurate diagnosis.
Area of Science:
- Gynecologic pathology
- Oncology
- Cellular biology
Background:
- Epithelioid tumor cells in uterine perivascular epithelioid cell tumors (PEComas) can be mistaken for carcinoma cells.
- This diagnostic challenge, known as a pitfall, can occur in endometrial sampling.
- Accurate differentiation is critical for appropriate patient management.
Purpose of the Study:
- To highlight the potential diagnostic pitfall of PEComa cells mimicking carcinoma in endometrial biopsies.
- To emphasize the utility of immunohistochemistry in distinguishing these entities.
Main Methods:
- Review of endometrial biopsy cases with epithelioid morphology.
- Application of immunohistochemical stains, including HMB45 and keratin.
Main Results:
- Epithelioid PEComa cells exhibit characteristic HMB45 positivity.
- These cells are typically negative for keratin, contrasting with common endometrial carcinomas.
Conclusions:
- Immunohistochemistry is essential for the differential diagnosis of uterine PEComa versus endometrial carcinoma.
- HMB45 positivity and keratin negativity are key markers for identifying PEComa in endometrial samples.
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