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Related Concept Videos

Applications of RC Circuits01:22

Applications of RC Circuits

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A relaxation oscillator is one of the applications of RC circuits. A neon lamp relaxation oscillator comprises a capacitor, a resistor, a voltage source, and a lamp. The lamp acts like an open circuit, with infinite resistance until the potential difference across the lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit with zero resistance, and the capacitor discharges through the lamp, thus producing light. Once the capacitor is fully discharged through the...
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Application of Integration: Problem Solving01:30

Application of Integration: Problem Solving

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The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
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Power Distribution in Three-phase and Single Phase Circuits01:17

Power Distribution in Three-phase and Single Phase Circuits

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Power distribution within electrical circuits is a foundational aspect of residential and industrial energy systems. While single-phase power is common in residential settings, three-phase power is the standard for industrial environments with heavy machinery. Each system is different and has advantages, and it's crucial to understand the underlying principles of power distribution and material efficiency.
Single-Phase Power Distribution:
Single-phase circuits are typical in household settings;...
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Second-Order Circuits01:17

Second-Order Circuits

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Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
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First-Order Circuits01:15

First-Order Circuits

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First-order electrical circuits, which comprise resistors and a single energy storage element - either a capacitor or an inductor, are fundamental to many electronic systems. These circuits are governed by a first-order differential equation that describes the relationship between input and output signals.
One common example of a first-order circuit is the RC (resistor-capacitor) circuit. These circuits are used in relaxation oscillators such as neon lamp oscillator circuits. When voltage is...
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The Y-to-Y Circuit01:19

The Y-to-Y Circuit

739
In a balanced four-wire wye-to-wye system, the arrangement involves wye-connected sinusoidal voltage sources and loads, connected through a neutral wire that links the neutral nodes of the source and load. The load impedance is connected across each phase of the load. The wye-connected source can be connected to the wye-connected load in four-wire and three-wire arrangements. A three-phase system is considered balanced when the load on each phase is equal, leading to uniform current flow and...
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Related Experiment Video

Updated: Jan 26, 2026

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Integrated Fluidic Circuits for Single-Cell Omics and Multi-omics Applications.

Mark Lynch1, Naveen Ramalingam2

  • 1Fluidigm Corporation, South San Francisco, CA, USA. mark.lynch@fluidigm.com.

Advances in Experimental Medicine and Biology
|April 11, 2019
PubMed
Summary

Single-cell multi-omics analyzes multiple cell components. Integrated fluidic circuit (IFC) microfluidics enhance sensitivity and flexibility for these advanced single-cell genomics applications.

Keywords:
FluidigmIntegrated Fluidic Circuits (IFC)Single-cell analysis

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Area of Science:

  • Single-cell biology
  • Genomics
  • Multi-omics

Background:

  • Single-cell genomics is vital for biological research, including developmental biology and the Cell Atlas initiative.
  • Current single-cell methods are evolving for higher throughput, sensitivity, accuracy, and reduced bias and cost.
  • There is significant interest in single-cell multi-omics, analyzing multiple analytes (genome, epigenome, transcriptome, protein) from individual cells.

Purpose of the Study:

  • To present integrated fluidic circuit (IFC) microfluidics for single-cell multi-omics.
  • To demonstrate how IFC technology complements existing single-cell platforms.
  • To discuss future applications of IFCs in emerging multi-omics research.

Main Methods:

  • Utilizing miniaturized microfluidic devices for enhanced reaction efficiency in nanoliter or picoliter volumes.
  • Employing solid-state microfluidic devices with active mixing for improved flexibility and sensitivity.
  • Focusing on integrated fluidic circuit (IFC) microfluidics for multi-step single-cell workflows.

Main Results:

  • IFC microfluidics offer increased reaction efficiency and sensitivity for single-cell analyses.
  • Automation of single-cell methods using IFCs aims for reproducible workflows and reduced errors.
  • IFC technology provides a flexible platform for diverse single-cell multi-omics applications.

Conclusions:

  • IFC microfluidics are a powerful technology for advancing single-cell multi-omics.
  • This technology integrates seamlessly with current single-cell platforms.
  • IFCs are poised for significant contributions to future multi-omics research horizons.