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Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes
Sung Woo Kim1, Jae Han Jeon2, Jun Sung Moon3
1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
Diabetes & Metabolism Journal
|April 11, 2019
Summary
Low free thyroxine (FT4) levels in euthyroid men are linked to higher glycosylated hemoglobin (HbA1c) and an increased risk of prediabetes, even within the normal thyroid function range.
Area of Science:
- Endocrinology
- Metabolic Health
- Thyroid Function
Background:
- Thyroid dysfunction impacts glucose metabolism.
- The role of subclinical thyroid hormone variations in prediabetes remains unclear.
Purpose of the Study:
- To investigate the association between free thyroxine (FT4) levels and prediabetes prevalence in euthyroid men.
- To determine if FT4 influences glycemic control markers like HbA1c and fasting plasma glucose (FPG).
Main Methods:
- Cross-sectional analysis of 2,399 euthyroid, non-diabetic men from the Korea National Health and Nutrition Examination Survey (2013-2015).
- Participants stratified into tertiles based on serum FT4 concentrations.
- Statistical adjustments for multiple confounding factors.
Main Results:
- Lower FT4 concentrations were observed in prediabetic individuals compared to those without prediabetes.
- Higher FT4 tertiles correlated with significantly decreased HbA1c levels (P<0.01).
- Prediabetes prevalence was significantly higher in the lowest FT4 tertile (OR 1.426, P<0.01).
Conclusions:
- Low-normal serum FT4 is associated with elevated HbA1c and increased prediabetes risk in euthyroid men.
- Serum FT4 concentration may serve as a risk factor for prediabetes, independent of overt thyroid dysfunction.
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