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Updated: Jan 26, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates
Md Raihan Sarkar1, Samrat Dasgupta, Simon M Pyke
1Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia. stephen.bell@adelaide.edu.au.
Abstract:
The cytochrome P450 monooxygenase CYP101B1 from Novosphingobium aromaticivorans selectively hydroxylated methylene C-H bonds in cycloalkyl rings. Cycloketones and cycloalkyl esters containing C6, C8, C10 and C12 rings were oxidised with high selectively on the opposite side of the ring to the carbonyl substituent. Cyclodecanone was oxidised to oxabicycloundecanol derivatives in equilibrium with the hydroxycyclodecanones.
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