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Effects of physical restraint on leukemogenesis by Friend virus
Abstract:
The effects of physical restraint on the development of Friend erythroleukemia in ddY mice were examined. Restraint was applied by immobilizing the mice in wire cages. In both sexes there was a reduction in the weight of the whole body, thymus and spleen, though the food intake was not reduced. The incidence of leukemia was reduced in the males, but not in the females, while the latent period was prolonged in both sexes. This sex dependency is characteristic of the stress response.
Insights
Physical restraint reduced body weight and spleen size in mice. Leukemia incidence decreased in males but not females, with a longer onset period for both sexes, indicating a sex-dependent stress response.
Area of Science:
- Stress physiology
- Oncology
- Animal models
Background:
- Physical restraint is a common stressor.
- The Friend erythroleukemia model is used to study cancer development.
- Sex differences in stress responses are well-documented.
Purpose of the Study:
- To investigate the impact of physical restraint stress on Friend erythroleukemia development in ddY mice.
- To determine if stress affects leukemia incidence, latency, and associated physiological changes.
- To explore potential sex-dependent effects of stress on leukemia progression.
Main Methods:
- ddY mice were subjected to physical restraint by immobilization in wire cages.
- Body weight, thymus, and spleen weights were measured.
- Food intake was monitored.
- Leukemia incidence and latent period were recorded.
Main Results:
- Restraint led to reduced body weight, thymus, and spleen weights in both male and female mice.
- Food intake remained unaffected by restraint.
- Leukemia incidence decreased in males but not in females.
- The latent period for leukemia development was prolonged in both sexes.
Conclusions:
- Physical restraint induces physiological stress responses in mice, including organ weight reduction.
- Stress has a sex-dependent effect on Friend erythroleukemia development, reducing incidence in males but not females.
- The prolonged latent period suggests stress can modulate cancer progression, with notable sex differences.