Copper and palladium-catalyzed sequential reactions: one-pot synthesis of isoindolo[2,1-b]isoquinolin-7(5H)-ones
Hitesh Kumar Saini1, Shiv Dhiman, Nitesh Kumar Nandwana
1Department of Chemistry, BITS Pilani, Pilani Campus, Pilani, Rajasthan 333031, India. anilkumar@pilani.bits-pilani.ac.in.
Abstract:
A highly efficient protocol has been developed for the synthesis of diversely substituted isoindolo[2,1-b]isoquinolin-7(5H)-ones through sequential Cu(ii)-catalyzed Sonogashira coupling, intramolecular hydroamidation followed by palladium-catalyzed ligand-free Heck reaction. Good to excellent yields (41-94%) were observed with excellent substrate scope and functional group tolerance. The developed method represents a practical strategy for the construction of bioactive isoindolo[2,1-b]isoquinolin-7(5H)-ones.
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