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Related Experiment Video

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Baroreflex sensitivity in frailty syndrome.

M S S Buto1, A M Catai1, V Vassimon-Barroso1

  • 1Departamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 11, 2019
PubMed
Summary

Frailty impairs cardiovascular homeostasis. Reduced baroreflex coherence (K2) in frail individuals suggests a decoupling between heart rate and blood pressure, potentially marking the frailty process.

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Area of Science:

  • Gerontology
  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Frailty is characterized by decreased physiological reserves, impacting homeostasis.
  • The baroreflex is a key mechanism for maintaining cardiovascular homeostasis.
  • Understanding baroreflex function in frailty is crucial for assessing cardiovascular health in older adults.

Purpose of the Study:

  • To compare baroreflex function among frail, prefrail, and nonfrail older adults.
  • To investigate the effects of supine and orthostatic positions on baroreflex parameters.
  • To identify potential baroreflex markers associated with the frailty process.

Main Methods:

  • Community-dwelling older adults were classified into frail, prefrail, and nonfrail groups based on the frailty phenotype.
  • Continuous recordings of RR interval (RRi) and systolic blood pressure (SBP) were obtained in supine and orthostatic positions.
  • Baroreflex was assessed using phase, gain (α), and coherence (K2), analyzed with repeated measures ANOVA.

Main Results:

  • Pre-frail and frail individuals showed no significant decrease in mean RRi during postural challenge.
  • Frail participants exhibited reduced RRi variance from supine to orthostatic positions.
  • Pre-frail and frail groups demonstrated decreased baroreflex coherence (K2) after postural change, with frail individuals showing the lowest K2 values.

Conclusions:

  • Reduced baroreflex coherence (K2) may serve as a marker for the frailty process.
  • Baroreflex analysis reveals a decoupling between heart period and SBP in prefrail and frail individuals.
  • These findings highlight impaired cardiovascular autonomic regulation in frailty.