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[Preliminary study on the relationship between OSA and renal function].

F Song1, H L Yi

  • 1Department of Otolaryngology Head and Neck Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Otolaryngology Institute of Shanghai Jiaotong University, Shanghai, 200233, China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|April 11, 2019
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) is linked to varying degrees of kidney function impairment. However, the relationship between OSA severity and renal dysfunction is not a simple linear one.

Keywords:
cystatin Crenal functionsleep apnea, obstructive

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Area of Science:

  • Nephrology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition associated with numerous health complications.
  • Kidney dysfunction is a potential comorbidity of OSA, but the precise relationship requires further elucidation.

Purpose of the Study:

  • To investigate the association between obstructive sleep apnea (OSA) and renal function.
  • To analyze the correlation between OSA severity and the degree of renal impairment.

Main Methods:

  • Clinical data from 487 patients undergoing sleep monitoring were analyzed.
  • Patients were categorized into non-OSA and various OSA severity groups (mild, moderate, severe, extremely severe).
  • Estimated glomerular filtration rate (eGFR) was calculated using serum creatinine and cystatin C; propensity score matching (PSM) was employed to control for confounders.

Main Results:

  • Serum cystatin C levels were significantly higher in patients with moderate and extremely severe OSA compared to controls.
  • Estimated glomerular filtration rate (eGFR) was significantly lower in patients with moderate and extremely severe OSA.
  • After PSM, elevated cystatin C persisted in moderate and extremely severe OSA groups, with reduced eGFR noted specifically in the moderate OSA group.

Conclusions:

  • Renal function impairment is present in patients with OSA, with varying degrees of severity.
  • The relationship between OSA severity and renal dysfunction does not follow a straightforward linear pattern.