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[Expression profiles of microRNA related to atherosclerosis in patients with OSA]

K Li1, Z T Chen, Y W Qin

  • 1Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|April 11, 2019
PubMed

Insights

Certain microRNAs (miRNAs) are upregulated in patients with obstructive sleep apnea (OSA) and atherosclerosis (AS). These specific miRNAs may serve as early warning markers for developing AS in OSA patients.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is increasingly linked to atherosclerosis (AS).
  • The molecular mechanisms connecting OSA and AS, particularly the role of microRNAs (miRNAs), require further elucidation.
  • Serum miRNAs are potential biomarkers for various diseases, including cardiovascular conditions.

Purpose of the Study:

  • To investigate the expression profiles of atherosclerosis-related serum miRNAs in patients with OSA.
  • To determine if specific miRNAs are associated with the presence and severity of AS in OSA patients.

Main Methods:

  • A cohort of 116 participants was analyzed, including normal controls, OSA patients, OSA with AS patients, and AS patients without OSA.
  • Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to profile serum miRNA expression.
  • Spearman correlations were employed to analyze associations between miRNA levels, clinical data, and lipid parameters.

Main Results:

  • Four miRNAs (miRNA-148a-5p, miRNA-378c, miRNA-127-3p, miRNA-365a-3p) were upregulated in OSA, OSA-AS, and AS groups compared to controls.
  • miRNA-134-5p was uniquely upregulated in the AS group.
  • Elevated levels of circulating atherosclerosis-related miRNAs correlated with carotid intima-media thickness.

Conclusions:

  • Upregulation of specific miRNAs (miRNA-148a-5p, miRNA-365a-3p, miRNA-378c, miRNA-127-3p) may indicate early-stage atherosclerosis in OSA patients.
  • These miRNAs show potential as novel biomarkers for identifying individuals at risk of developing AS in the context of OSA.
Keywords:
atherosclerosismicroRNAsleep apnoea, obstructive

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