Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.3K
Seedless Vascular Plants03:24

Seedless Vascular Plants

66.7K
Seedless Vascular Plants Were the First Tall Plants on Earth
66.7K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

887
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
887
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

493
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
493
Vascular Spasm01:16

Vascular Spasm

3.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
3.4K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling.

Current issues in molecular biology·2026
Same author

Enhanced chemoimmunotherapy of breast cancer in mice by apolipoprotein A1-modified doxorubicin liposomes combined with interleukin-21.

Journal of drug targeting·2023
Same author

Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8<sup>+</sup> T cells and the exclusion of Treg cells.

Frontiers in immunology·2022
Same author

An engineered IL-21 with half-life extension enhances anti-tumor immunity as a monotherapy or in combination with PD-1 or TIGIT blockade.

International immunopharmacology·2021
Same author

Reversal of Multidrug Resistance by Apolipoprotein A1-Modified Doxorubicin Liposome for Breast Cancer Treatment.

Molecules (Basel, Switzerland)·2021
Same author

Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum.

Applied microbiology and biotechnology·2020

Related Experiment Video

Updated: Jan 26, 2026

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

9.6K

Fenofibrate improves vascular endothelial function in diabetic mice.

Rujuan Xin1, Duopeng An1, Ying Li1

  • 1Department of Pharmacy, Shanghai Skin Disease Hospital, Shanghai, 200443, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|April 12, 2019
PubMed
Summary

Fenofibrate improves blood vessel function in diabetic mice by reducing oxidative stress and enhancing nitric oxide production. This treatment activates key proteins, potentially offering a new strategy for managing diabetic vascular complications.

Keywords:
DiabetesEndothelial dysfunctionFenofibrateMouse aortic endothelial cellseNOS

More Related Videos

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.6K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K

Related Experiment Videos

Last Updated: Jan 26, 2026

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

9.6K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.6K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic complications, including vascular damage, are linked to high blood glucose levels.
  • Endothelial dysfunction is a key factor in diabetic microvascular and macrovascular issues.
  • Fenofibrate, a PPARα agonist, has shown potential in reducing cardiovascular events in diabetics.

Purpose of the Study:

  • To investigate if fenofibrate can improve endothelium-dependent vasodilation in diabetic mice.
  • To determine if fenofibrate alleviates high glucose-induced endothelial dysfunction by activating eNOS and AMPK.
  • To explore the molecular mechanisms underlying fenofibrate's effects on diabetic vasculature.

Main Methods:

  • A streptozotocin (STZ)-induced diabetic mouse model was used.
  • Fenofibrate was administered orally to diabetic mice for 14 days.
  • Endothelial function was assessed via vasodilation assays; oxidative stress (O2-) and protein phosphorylation (eNOS, AMPK) were measured.

Main Results:

  • Fenofibrate treatment improved endothelium-dependent relaxation in diabetic mouse aortae.
  • Fenofibrate reduced superoxide levels in diabetic aortae and cultured endothelial cells.
  • Fenofibrate activated eNOS and AMPK phosphorylation in high glucose-exposed endothelial cells, increasing nitric oxide production.

Conclusions:

  • Fenofibrate ameliorates impaired vasodilation and endothelial dysfunction in diabetic mice.
  • The protective effects of fenofibrate are associated with reduced oxidative stress and activation of eNOS and AMPK.
  • Fenofibrate shows promise as a therapeutic agent for diabetic vascular complications.