Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The German National Strategy for Gene- and Cell-Based Therapies: Generating Impact by Employing a Novel Multi-Stakeholder Approach.

Human gene therapy·2026

Same author

Investigation of the intake process of different tablets by assessment of swallowability and palatability as well as measurement of deglutition parameters by electromyography and bioimpedance analysis.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026

Same author

Microbubbles manufactured using a tissue homogeniser: DoE-guided optimisation for a narrower size distribution and higher yield.

International journal of pharmaceutics·2026

Same author

Integrating Social Care into Pharmacy Interprofessional Education Through Holistic Collaborative Learning.

American journal of pharmaceutical education·2026

Same author

Sensory-driven micro-interventions for improved health and wellbeing.

Digital health·2025

Same author

Efficacy and safety of microbiota-targeted therapeutics in autoimmune and inflammatory rheumatic diseases: protocol for a systematic review and meta-analysis of randomised controlled trials.

BMJ open·2025

Search research articles

Related Experiment Video

Updated: Jan 26, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

Age-Related Medicine.

John Wahlich¹, Mine Orlu², Alpana Mair³

¹Academy of Pharmaceutical Sciences, 4 Heydon Road, Great Chishill, Royston, Herts SG8 8SR, UK. John.Wahlich@btinternet.com.

|April 12, 2019

Summary

This summary is machine-generated.

Developing medicines for older adults presents unique challenges due to polypharmacy and changing risk-benefit profiles. Pharmaceutical scientists must consider age-specific needs for new and existing medications.

Keywords:

SIMPATHY ageing multiple morbidities pharmaceutical sciences polypharmacy product development

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Related Experiment Videos

Last Updated: Jan 26, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Area of Science:

Pharmaceutical Sciences
Geriatric Medicine
Drug Development

Background:

Meeting focused on challenges in developing medicines for the aging population.
Addressed complexities of polypharmacy and multiple morbidities in older adults.
Explored how the risk-benefit ratio of medications shifts with aging.

Framework:

Discussed regulatory encouragement for age-appropriate medicine development.
Highlighted difficulties older adults face with current medicinal products.
Provided suggestions for incorporating geriatric needs into drug design.

Implementation:

Pharmaceutical scientists can integrate older adult requirements into new drug development.
Improvements to existing medicines can be made to better suit the elderly.
Focus on age-specific formulation and dosage considerations.

Implications:

Enhanced safety and efficacy of medications for the older population.
Improved therapeutic outcomes and quality of life for geriatric patients.
Advancement in geriatric pharmacotherapy and pharmaceutical sciences.