Related Experiment Video

Updated: Jan 26, 2026

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

3.3K

Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective

María Ángeles Jiménez-Sousa1, Ana Zaida Gómez-Moreno2, Daniel Pineda-Tenor3

  • 1Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Spain. jimenezsousa@isciii.es.

Biomolecules
|April 12, 2019
PubMed

Insights

The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism influences hepatitis C progression. Patients with the DARC rs12075 AG/GG genotype show a reduced risk of liver fibrosis and cirrhosis development.

Area of Science:

  • Genetics and Immunology
  • Hepatology and Viral Hepatitis Research

Background:

  • Hepatitis C virus (HCV) infection leads to liver fibrosis driven by uncontrolled inflammation.
  • The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism is known to regulate leukocyte trafficking and chemokine balance.

Purpose of the Study:

  • To investigate the association between the DARC rs12075 polymorphism and the progression of liver stiffness in patients with chronic hepatitis C (CHC).
  • To determine if specific DARC rs12075 genotypes influence the rate of liver fibrosis progression and cirrhosis development in HCV-infected individuals.

Main Methods:

  • A retrospective cohort study involving 208 noncirrhotic CHC patients with at least two liver stiffness measurements (LSM) over a minimum 12-month interval.
  • Generalized linear models were employed to analyze the relationship between DARC rs12075 genotypes and liver stiffness progression.
  • Patient data were followed for an average of 46.6 months to assess changes in fibrosis stages and LSM.

Main Results:

  • Over the follow-up period, a significant decrease in early fibrosis stages (F0/F1) and a significant increase in LSM values and cirrhosis prevalence were observed.
  • Patients with the DARC rs12075 AG/GG genotype exhibited lower variations in liver stiffness compared to the AA genotype.
  • The AG/GG genotype was associated with a significantly lower risk of increased LSM (mean ratio 0.83, OR 0.28) and cirrhosis progression (OR 0.24).

Conclusions:

  • The DARC rs12075 single nucleotide polymorphism is associated with the progression of chronic hepatitis C.
  • Individuals carrying the DARC rs12075 AG/GG genotype demonstrate a reduced risk of liver fibrosis progression and the development of cirrhosis.
  • These findings highlight the potential role of DARC rs12075 genotype in modulating inflammatory responses and disease outcomes in HCV infection.

Keywords:
DARCchronic hepatitis Ccirrhosishepatic fibrosisliver stiffnesssingle nucleotide polymorphisms

More Related Videos

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI06:09

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Published on: July 21, 2023

1.9K
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.9K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
190
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.0K
Impact of Groups on Groups01:19

Impact of Groups on Groups

Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
238
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
747
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
267