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Updated: Jan 26, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Biodegradable Core⁻Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of
Michael L Unbehauen1, Emanuel Fleige2,3, Florian Paulus4,5
1Freie Universität Berlin, Institute for Chemistry and Biochemistry, Takustraße 3, 14195 Berlin, Germany. m.unbehauen@fu-berlin.de.
Abstract:
We here present the synthesis and characterization of a set of biodegradable core⁻multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.
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