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Updated: Jul 8, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Placebo-controlled double-blind food challenge in asthma
The Journal of Allergy and Clinical Immunology
|December 1, 1986
Summary
Food allergy can trigger asthma exacerbations, but it is uncommon. Disodium cromoglycate may help manage food allergy-induced asthma, complementing elimination diets for diagnosed patients.
Area of Science:
- Allergy and Immunology
- Pulmonology
- Clinical Medicine
Background:
- Food allergy is a potential trigger for asthma exacerbations.
- Identifying the role of food allergy in asthma requires careful diagnostic evaluation.
- Asthma management often involves addressing all potential triggers.
Purpose of the Study:
- To investigate the prevalence of food allergy as a cause of asthma exacerbations.
- To evaluate the efficacy of disodium cromoglycate in managing food allergy-induced asthma.
Main Methods:
- Screening of 300 asthma patients using questionnaires, skin prick tests, and RAST.
- Double-blind food challenges performed on patients with suggestive allergy indicators.
- Pulmonary function tests and symptom monitoring for 8 hours post-challenge.
Main Results:
- Only 25 out of 300 patients showed signs suggestive of food allergy.
- Food challenges confirmed food allergy as the cause of asthma in 6 patients and other symptoms in 5.
- Disodium cromoglycate blocked asthmatic responses in 4 out of 5 subjects upon rechallenge.
Conclusions:
- Food allergy is an infrequent cause of asthma exacerbations, even in specialty clinics.
- Avoid indiscriminate food elimination diets or allergen testing for all asthma patients.
- Disodium cromoglycate can be a useful adjunct to elimination diets for confirmed food allergy-induced asthma.
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