Related Experiment Video
Updated: Jan 26, 2026
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chiral BINOL-Based Covalent Organic Frameworks for Enantioselective Sensing.
Xiaowei Wu1, Xing Han1, Qisong Xu2
1School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai 200240 , China.
Chiral fluorescent covalent organic frameworks (COFs) were synthesized using BINOL building blocks for enantioselective sensing. These COFs demonstrate enhanced sensitivity and selectivity in detecting chiral vapors, advancing porous materials for chirality applications.
Area of Science:
- Materials Science
- Organic Chemistry
- Nanotechnology
Background:
- Covalent organic frameworks (COFs) offer a versatile platform for designing functional materials.
- Chirality is crucial in synthesis and materials science, with 1,1'-bi-2-naphthol (BINOL) being a key chiral source.
- Integrating BINOL into COFs for enantioselective applications remained an unexplored area.
Purpose of the Study:
- To synthesize novel chiral fluorescent COFs incorporating BINOL for enantioselective processes.
- To investigate the potential of these COFs as chiral vapor sensors.
- To enhance chiral discrimination capabilities through framework confinement.
Main Methods:
- Designed and synthesized two imine-linked chiral fluorescent COFs using enantiopure BINOL-based dialdehyde and amine building blocks.
- Exfoliated a BINOL-COF into ultrathin 2D nanosheets and fabricated free-standing nanofiber membranes.
- Evaluated the fluorescence quenching response of COF nanosheets and membranes to chiral odor vapors.
Main Results:
- Two novel 2D layered chiral fluorescent COFs with hexagonal and tetragonal structures were successfully prepared.
- The BINOL-COF nanosheets exhibited effective fluorescence quenching upon interaction with chiral odor vapors.
- Compared to homogeneous systems, COF nanosheets demonstrated significantly enhanced sensitivity and enantioselectivity in chiral vapor sensing due to confinement effects.
Conclusions:
- Developed a new strategy for constructing chiral COFs using BINOL for advanced enantioselective applications.
- Demonstrated the efficacy of BINOL-COFs as highly sensitive and selective chiral vapor sensors.
- Highlighted the potential of porous materials in amplifying chiral discrimination for broader applications.
More Related Videos
08:42Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
Published on: July 10, 2017
04:53Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
Published on: May 26, 2023
Related Concept Videos
01:29Covalent Bonds
01:08Covalent Bonds
When two atoms share electrons to complete their valence shells, they create a covalent bond. An atom's electronegativity—the force with which shared electrons are pulled towards an atom—determines how the electrons are shared. Molecules formed with covalent bonds can be either polar or nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds; the electrons are shared equally. Atoms with different electronegativities share electrons unequally,...
02:18Network Covalent Solids
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
02:25Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
02:04Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
02:46Covalent Bonding and Lewis Structures