Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flow Sheet01:17

Flow Sheet

2.7K
Flowsheets are valuable tools in nursing documentation. They enable healthcare professionals to efficiently record and monitor various patient assessments and measurements in a consolidated format.
Here's a closer look at the examples of flowsheets commonly used by nurses:
Graphic Sheet Documentation:
2.7K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Plant Cells and Tissues02:01

Plant Cells and Tissues

65.5K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.5K
Tissues01:18

Tissues

84.9K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
84.9K
Bode Plots Construction01:24

Bode Plots Construction

1.1K
The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
1.1K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effectiveness of Platelet Rich Fibrin in Alveolar Ridge Reconstructive or Guided Bone Regenerative Procedures: A Systematic Review and Meta-Analysis.

Journal of dentistry·2024
Same author

Author Correction: Evidence for multi-fragmentation and mass shedding of boulders on rubble-pile binary asteroid system (65803) Didymos.

Nature communications·2024
Same author

The Therapeutic Use of Dental Mesenchymal Stem Cells in Human Clinical Trials.

Journal of dental research·2024
Same author

Evidence for multi-fragmentation and mass shedding of boulders on rubble-pile binary asteroid system (65803) Didymos.

Nature communications·2024
Same author

A comparison of occupational physical activity and sedentary behavior patterns of nurses working 12-h day and night shifts.

International journal of nursing studies advances·2024
Same author

Corrigendum to "A human factors approach to evaluate predictors of acute care nurses occupational fatigue" [Appl. Ergon. 100 (2022) 103647-1-10].

Applied ergonomics·2024
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.1K

Periodontal Tissue Engineering with a Multiphasic Construct and Cell Sheets.

C Vaquette1,2,3, S Saifzadeh1,2, A Farag3

  • 11 Queensland University of Technology, Brisbane, Australia.

Journal of Dental Research
|April 12, 2019
PubMed
Summary
This summary is machine-generated.

This study used a biphasic scaffold with cell sheets for periodontal regeneration in sheep. Bone marrow-derived mesenchymal stromal cells and periodontal ligament cells showed superior results compared to gingival cells.

Keywords:
biocompatible materialscell transplantationcementogenesisosteogenesisperiodontal ligamenttissue scaffolds

More Related Videos

Fabrication of Myogenic Engineered Tissue Constructs
13:43

Fabrication of Myogenic Engineered Tissue Constructs

Published on: May 1, 2009

10.9K
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.8K

Related Experiment Videos

Last Updated: Jan 26, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.1K
Fabrication of Myogenic Engineered Tissue Constructs
13:43

Fabrication of Myogenic Engineered Tissue Constructs

Published on: May 1, 2009

10.9K
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Periodontology

Background:

  • Periodontal disease leads to significant tissue loss.
  • Current treatments have limitations in fully regenerating periodontal structures.
  • Scaffold-based tissue engineering offers a promising approach for periodontal regeneration.

Purpose of the Study:

  • To evaluate a biphasic scaffold delivering cell sheets for periodontal tissue regeneration in a large animal model.
  • To compare the regenerative potential of gingival cells (GCs), bone marrow-derived mesenchymal stromal cells (Bm-MSCs), and periodontal ligament cells (PDLCs).

Main Methods:

  • A biphasic scaffold with distinct bone and periodontal ligament compartments was fabricated using electrospinning.
  • In vitro matured cell sheets from GCs, Bm-MSCs, and PDLCs were delivered via the scaffold.
  • Surgically created periodontal defects in sheep were treated with the constructs and assessed radiographically and histologically at 5 and 10 weeks.

Main Results:

  • The biphasic constructs maintained shape and integrated well with host tissues.
  • Excellent integration was observed between scaffold compartments and the tooth root interface.
  • Bone coverage and periodontal regeneration, including new bone and cementum formation with fiber attachment, increased over time in Bm-MSC and PDLC groups.
  • PDLC group showed greater bone fill compared to the empty scaffold at 10 weeks.
  • GC group demonstrated inferior bone regeneration compared to other groups.

Conclusions:

  • Scaffold-based periodontal tissue engineering is feasible in a large preclinical model.
  • Biphasic constructs support periodontal regeneration, with Bm-MSCs and PDLCs yielding superior outcomes over GCs.
  • This approach holds potential for clinical applications in treating periodontal defects.