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Updated: Jan 26, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
Abhik Saha1, Erle S Robertson2
1Department of Life Sciences, Presidency University, Kolkata, West Bengal, India abhik.dbs@presiuniv.ac.in erle@upenn.edu.
Abstract:
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis.
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