Related Experiment Video
Updated: Jan 26, 2026

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
Published on: July 4, 2018
Role of Per3, a circadian clock gene, in embryonic development of mouse cerebral cortex
Mariko Noda1, Ikuko Iwamoto1, Hidenori Tabata1
1Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan.
Abstract:
Per3 is one of the primary components of circadian clock system. While circadian dysregulation is known to be involved in the pathogenesis of several neuropsychiatric diseases. It remains largely unknown whether they participate in embryonic brain development. Here, we examined the role of clock gene Per3 in the development of mouse cerebral cortex. In situ hybridization analysis revealed that Per3 is expressed in the developing mouse cortex. Acute knockdown of Per3 with in utero electroporation caused abnormal positioning of cortical neurons, which was rescued by RNAi-resistant Per3. Per3-deficient cells showed abnormal migration phenotypes, impaired axon extension and dendritic arbor formation. Taken together, Per3 was found to play a pivotal role in corticogenesis via regulation of excitatory neuron migration and synaptic network formation.
Related Concept Videos
Circadian Rhythms and Gene Regulation
Role of Cerebellum and Prefrontal Cortex in Memory
Biological Clocks and Seasonal Responses
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Embryonic Stem Cells

