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Updated: Jan 26, 2026

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
Published on: February 18, 2017
Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets
Adriane Penczek1, Timo Burster2
1Department of Neurosurgery, Ulm University Medical Center, D-89081 Ulm, Germany.
Abstract:
The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of immune cells to provoke the proteolytic processing of cytokines and chemokines in order to stimulate lymphocytes. The present study analyzed peripheral blood mononuclear cells to characterize T cell populations in terms of their CatG content by flow cytometry. It was identified that CatG was exclusively present on the cell surface of a subset of T regulatory cells (Tregs), cluster of differentiation (CD) 39+ Tregs, which expressed CatG in contrast to CD39- Tregs. Additionally, CatG was expressed on double positive CD4+CD8+ T cells, T helper (Th) 9 cells and Th22 cells, implicating CatG as a novel marker to distinguish certain T cell subsets.
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