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Partial Hepatectomy in Adult Zebrafish

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Published on: April 4, 2021

Can IVIM help predict HCC recurrence after hepatectomy?

Yao Zhang¹, Sichi Kuang¹, Qungang Shan¹

¹Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University (SYSU), No 600, Tianhe Road, Guangzhou, 510630, People's Republic of China.

European Radiology

|April 12, 2019

Summary

This summary is machine-generated.

The D value from intravoxel incoherent motion (IVIM) imaging can predict hepatocellular carcinoma (HCC) recurrence after surgery. Combining this D value with age and alpha-fetoprotein (AFP) levels improves prediction accuracy.

Keywords:

Diffusion Hepatitis B virus (HBV)Hepatocellular carcinoma (HCC)Magnetic resonance imaging (MRI)Recurrence

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Area of Science:

Radiology and Imaging
Oncology
Hepatology

Background:

Hepatocellular carcinoma (HCC) is a major global health concern, particularly in patients with chronic hepatitis B virus (HBV) infection.
Hepatectomy remains a primary curative treatment for HCC, but tumor recurrence is a significant challenge.
Predictive biomarkers are crucial for identifying patients at high risk of recurrence post-hepatectomy.

Purpose of the Study:

To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) parameters in predicting tumor recurrence after hepatectomy in HBV-related HCC.
To identify IVIM parameters that serve as independent predictors of HCC recurrence.

Main Methods:

A cohort of 157 patients with surgically confirmed HCC underwent preoperative MRI to obtain apparent diffusion coefficient (ADC) and IVIM parameters (D, D*, f).
Cox proportional hazards models were employed to analyze predictors of tumor recurrence.
Receiver operating characteristic (ROC) analysis was used to assess the predictive performance of the models.

Main Results:

Tumor recurrence was observed in 29.9% of patients.
A lower D value (< 0.985 × 10⁻³ mm²/s) was identified as a significant risk factor for recurrence (HR, 0.190; p=0.023).
Younger age and higher serum alpha-fetoprotein (AFP) levels were also associated with increased recurrence risk. The area under the curve (AUC) for predicting recurrence improved from 0.68 (age and AFP) to 0.724 (D value, age, and AFP).

Conclusions:

The D value derived from IVIM imaging is a promising preoperative biomarker for predicting HCC recurrence after hepatectomy.
Integrating the D value with clinical factors like age and AFP levels enhances the predictive accuracy for tumor recurrence in HBV-related HCC.