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Updated: Jan 26, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
Published on: December 26, 2011
Glucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series
Jacqueline N Poston1,2,3,4, Terry B Gernsheimer5,6
1Division of Hematology, Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356330, Seattle, WA, 98195, USA.
Abstract:
A proportion of patients with immune thrombocytopenic purpura are refractory to multiple therapies including thrombopoietin-receptor agonists (TPO-RA). We report 10 patients who did not respond to a TPO-RA until the addition of a glucocorticoid. These patients were previously treated with a median of 6 therapies. One patient elected to discontinue both medications despite persistent thrombocytopenia. The remaining 9 patients continued on the combination of prednisone (doses 5 mg every other day to 10 mg daily) and a TPO-RA. Combination therapy with low dose glucocorticoid and a TPO-RA may be an option for patients unresponsive to a TPO-RA alone.
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