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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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The internal combustion engine is a heat engine that uses the byproducts of combustion as the working fluid instead of using a heat transfer medium to transfer heat. The combustion is done in a way that produces high-pressure combustion products that can be expanded through a turbine or piston to create work. Internal combustion engines can again be categorized into three kinds: (1) spark ignition gasoline engines, most commonly used in automobiles, (2) compression ignition diesel engines that...
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Gross Anatomy of the Lungs01:17

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Updated: Jan 26, 2026

Engineered Lung Tissues Prepared from Decellularized Lung Slices
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Lung tissue engineering: An update.

Hamid Tebyanian1, Ali Karami1,2, Mohammad Reza Nourani2

  • 1Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Journal of Cellular Physiology
|April 12, 2019
PubMed
Summary
This summary is machine-generated.

Lung tissue engineering using decellularized extracellular matrix scaffolds and bioreactors offers a promising solution to the organ shortage for pulmonary disease patients. This approach aims to overcome current transplantation limitations.

Keywords:
in vivolungscaffoldstem celltissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Pulmonary Medicine

Background:

  • Pulmonary diseases pose a global health challenge, leading to reduced quality of life and increased mortality.
  • Lung transplantation is limited by organ availability and lifelong immunosuppression requirements.
  • Decellularization approaches are emerging as a novel strategy for lung tissue engineering.

Purpose of the Study:

  • To critically review the components of lung tissue engineering.
  • To appraise the recent literature (last 5 years) on lung tissue engineering strategies.
  • To highlight challenges and future directions in developing functional lungs.

Main Methods:

  • Review of scientific literature focusing on lung tissue engineering components.
  • Analysis of decellularized extracellular matrix scaffolds and bioreactor systems.
  • Evaluation of stem cell sources and growth factors for lung regeneration.

Main Results:

  • Decellularized extracellular matrix scaffolds are currently favored for lung tissue engineering.
  • Bioreactors need to be easily sterilizable, physiologically stimulating, and clinically translatable.
  • Key challenges include developing an endothelialized microvascular network and sufficient alveolar-capillary surface area for gas exchange.

Conclusions:

  • Lung tissue engineering holds significant potential to address the unmet clinical need for lung transplantation.
  • Advancements in scaffold technology, cell sourcing, and bioreactor design are crucial for success.
  • Overcoming challenges in vascularization and alveolar development is essential for creating functional engineered lungs.