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Updated: Jan 26, 2026

Establishment and Culture of Patient-Derived Breast Organoids
Published on: February 17, 2023
Screening breast MRI in patients with history of atypia or lobular neoplasia
Sona A Chikarmane1,2, Catherine S Giess1,2
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Abstract:
Our goal was to determine outcomes of screening breast MRI in patients with prior history of atypia or lobular neoplasia (LN). Review of the MRI data base revealed 264/7482 (3.5%) screening MRIs in 145 patients with history of atypia or LN. Overall, 39/264 (14.7%) received an abnormal interpretation, with 7.2% BI-RADS 4 and 5 (19/264) and 7.6% BI-RADS 3 (20/264). PPV1 was 38.4% (six cancers in 39 BI-RADS 3, 4, 5); PPV3 was 28.5% (six cancers in 21 biopsies). Screening breast MRI use in this population is low (3.5%), although PPVs are comparable to other high-risk groups for which breast MRI is recommended.
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