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Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
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Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

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[Treatment of the advanced HCC: A second revolution by using immunotherapy]

Laetitia Fartoux1, Olivier Rosmorduc1

  • 1Service d'Hépato-Gastro-Entérologie, Hôpital de la Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013, Paris, France.

Biologie Aujourd'Hui
|April 12, 2019
PubMed

Insights

Advanced hepatocellular carcinoma treatment was limited until new oral drugs and immunotherapy emerged. Immunotherapy shows promise for correcting the tumor

Area of Science:

  • Hepatobiliary oncology
  • Medical oncology
  • Cancer immunotherapy

Background:

  • Advanced hepatocellular carcinoma (HCC) treatment options were historically limited.
  • Cirrhosis often compromises patient tolerance to conventional chemotherapy.
  • Sorafenib, a targeted anti-angiogenic therapy, was the sole option for a decade.

Purpose of the Study:

  • To review the evolution of treatment strategies for advanced hepatocellular carcinoma.
  • To highlight the impact of newly validated oral molecules.
  • To discuss the emerging role of immunotherapy in advanced HCC.

Main Methods:

  • Review of clinical trial data and therapeutic guidelines.
  • Analysis of treatment outcomes for advanced HCC.
  • Evaluation of the potential of novel therapeutic agents.

Main Results:

  • New oral molecules have been validated, expanding treatment options.
  • Immunotherapy demonstrates significant promise by addressing the tumor's immunosuppressive microenvironment.
  • These advancements challenge the existing therapeutic algorithm for advanced HCC.

Conclusions:

  • The therapeutic landscape for advanced HCC is rapidly evolving.
  • Immunotherapy represents a paradigm shift, offering new hope for patients.
  • Further research is warranted to integrate these novel therapies effectively.

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