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Epigenetics in dilated cardiomyopathy

Junyi Yu1,2, Chunyu Zeng2, Yibin Wang1

  • 1Departments of Anesthesiology, Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, California, USA.

Current Opinion in Cardiology
|April 12, 2019
PubMed

Insights

Epigenetic alterations, including DNA methylation and noncoding RNAs, contribute to dilated cardiomyopathy (DCM). Understanding these epigenetic changes offers new diagnostic and therapeutic strategies for DCM.

Area of Science:

  • Cardiology
  • Genetics
  • Epigenetics

Background:

  • Dilated cardiomyopathy (DCM) is a leading cause of heart failure, characterized by ventricular enlargement and impaired systolic function.
  • While genetic mutations are known causes, epigenetic alterations are increasingly recognized as significant contributors to DCM development.

Purpose of the Study:

  • To review recent advancements in the field of epigenetics concerning dilated cardiomyopathy.
  • To highlight the roles of DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs in DCM.
  • To discuss the diagnostic and therapeutic implications of epigenetic regulation in DCM.

Main Methods:

  • Focus on four major epigenetic modifications: DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs.
  • Identification of key molecular players involved in DCM-related epigenetic reprogramming.
  • Review of current literature on epigenetic mechanisms in DCM.

Main Results:

  • Epigenetic modifications play a crucial role in the pathogenesis of DCM.
  • Specific epigenetic alterations and their associated molecular players are identified in DCM.
  • Emerging evidence suggests potential for epigenetic biomarkers and therapeutic targets in DCM.

Conclusions:

  • Epigenetic studies in DCM are rapidly expanding, offering novel mechanistic insights.
  • Epigenetic reprogramming presents promising new avenues for the effective treatment of dilated cardiomyopathy.
  • Further research into epigenetic regulation could lead to improved diagnostics and therapies for DCM.
Abstract

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