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Updated: Jan 26, 2026
11:27
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
10.5K
Update on Gadolinium-Based Contrast Agent-Enhanced Imaging in the Genitourinary System
Nicola Schieda1, Satheesh Krishna2, Matthew S Davenport3
1Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Rm C159, Ottawa, ON K1Y 4E9, Canada.
AJR. American Journal of Roentgenology
|April 12, 2019
Summary
Gadolinium-based contrast agents (GBCAs) are useful in genitourinary MRI, but their necessity varies by condition. Newer agents have minimal risk of nephrogenic systemic fibrosis, though retention and cost are emerging concerns.
Area of Science:
- Radiology
- Medical Imaging
- Genitourinary Imaging
Background:
- Gadolinium-based contrast agents (GBCAs) are widely used in MRI.
- Their application in the genitourinary (GU) system requires careful consideration of benefits and risks.
Purpose of the Study:
- To review the applications of GBCA-enhanced MRI in the genitourinary system.
- To discuss emerging considerations regarding GBCA use in GU imaging.
Main Methods:
- Literature review of GBCA-enhanced MRI in the GU system.
- Analysis of current guidelines and emerging research on GBCA safety and efficacy.
Main Results:
- Nephrogenic systemic fibrosis is rare with standard dosing of group II GBCAs.
- GBCA is not required for diagnosing adrenal adenomas, simple cysts, and some Bosniak II cysts.
- GBCA is essential for evaluating enhancement in solid or septal renal masses.
- Dynamic contrast-enhanced MRI remains valuable for selected prostate MRI examinations, particularly when high-quality diffusion-weighted imaging (DWI) is needed.
Conclusions:
- GBCA use in GU MRI is condition-dependent.
- Safety profiles of newer GBCAs are favorable regarding nephrogenic systemic fibrosis.
- Gadolinium retention, cost, and examination duration are key factors influencing GBCA utilization.
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