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Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J Ingham1,2, Selina A Pearson1, Valerie E Vancollie1
1Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Plos Biology
|April 12, 2019
Summary
This study identified 38 new genes linked to adult-onset hearing loss through mouse genetic screening. These findings reveal novel molecular pathways for progressive hearing loss and potential therapeutic targets.
Area of Science:
- Genetics
- Neuroscience
- Otolaryngology
Background:
- Adult-onset hearing loss is prevalent, yet its molecular causes remain largely unknown, hindering therapeutic development.
- Understanding the genetic basis of hearing loss is crucial for developing effective treatments.
Purpose of the Study:
- To identify novel genes and molecular pathways involved in adult-onset hearing loss using a genetic screening approach.
- To uncover new therapeutic targets for hearing loss by investigating genetic heterogeneity and progressive auditory pathologies.
Main Methods:
- A large-scale genetic screen of mouse mutants was conducted.
- Auditory brainstem response (ABR) testing was used to assess hearing function.
- Analysis of 1,211 genes identified those associated with elevated hearing thresholds.
Main Results:
- Thirty-eight previously unrecognized genes were found to be associated with hearing loss.
- A diverse range of auditory pathologies were observed in the screened mouse mutants.
- New molecular pathways contributing to progressive hearing loss were identified, with some genes linked to human hearing variation and childhood deafness (SPNS2).
Conclusions:
- The genetic screening revealed significant heterogeneity in the genetic causes of hearing loss.
- The identified molecular pathways offer promising new avenues for therapeutic interventions in hearing loss.
- This research advances the understanding of hearing maintenance and provides a foundation for future otologic therapies.
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