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Postnatal growth in preterm infants during the first year of life: A population-based cohort study in China
Leni Kang1, Huiqing Wang2, Chunhua He1
1National Office for Maternal and Child Health Surveillance of China, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Insights
Preterm infants show faster postnatal growth in weight and length than term infants, particularly in the first six months. However, they may not catch up to term peers until 12 months of age.
Area of Science:
- Pediatrics
- Neonatology
- Child Health
Background:
- Postnatal growth is a significant concern for preterm infants (born before 37 weeks gestation).
- Understanding growth trajectories is crucial for optimizing infant health outcomes.
Purpose of the Study:
- To investigate the postnatal growth patterns in weight and length of preterm infants.
- To compare growth rates between preterm and term infants, considering gender differences.
Main Methods:
- Utilized multicenter longitudinal data from China's Under 5 Child Nutrition and Health Surveillance System.
- Included 1221 preterm infants and 1221 matched term infants for comparison.
- Assessed gender-stratified differences in weight and length between the two groups.
Main Results:
- Preterm infants exhibited higher rates of weight and length growth than term infants, especially from 1 to 6 months.
- Male preterm infants showed faster growth rates than females in the first 3 months.
- Differences in weight and length between preterm and term infants diminished with age, but preterm infants did not reach term infant levels until 12 months (unadjusted for gestational age).
- Median weight and length were higher in preterm infants during the first month post-adjustment for gestational age.
Conclusions:
- Preterm infants demonstrate accelerated early postnatal growth, with some catch-up growth observed over the first year.
- Gender influences early growth rates in preterm infants.
- Gestational age adjustment is important for accurate interpretation of early growth data in preterm infants.
Abstract:
In preterm infants (i.e. the gestational age less than 37 weeks), postnatal growth remains a concern. This study used multicenter longitudinal data from China's Under 5 Child Nutrition and Health Surveillance System to investigate the postnatal growth in the weight and length of preterm infants. Gender-stratified differences in weight and length were assessed between preterm and term infants. 1221 preterm infants and 1221 matched term infants were included. The rates of growth in weight and length in preterm infants was greater than those in term infants, especially from the first to sixth month. The rates were higher in males compared to females in the first 3 months. The differences of weight and length between preterm and term infants decreased with increasing age, however, these measurements did not reach the level of their term peers until 12 months before adjusting for gestational age. The median values of weight and length were even larger in preterm infants in the first month after adjusting for gestational age.
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