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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Polytene Chromosomes02:04

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Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
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Lampbrush Chromosomes01:51

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In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
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Chromatin Packaging02:21

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
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Chromosome Structure02:40

Chromosome Structure

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A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
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Author Spotlight: RNAi Inheritance and ChIP in C. elegans
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40th International Asilomar Chromatin, Chromosomes, and Epigenetics Conference.

Zoe E Gillespie1,2, Tanner Barkhshi3,4, Maria Laura Sosa Ponce5,6

  • 1Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|April 12, 2019
PubMed
Summary

The 40th International Asilomar Chromatin, Chromosomes, and Epigenetics Conference convened in 2018, gathering experts to discuss advancements in chromatin, chromosomes, and epigenetics research.

Keywords:
chromatinchromatinechromosomeepigeneticsépigénétique

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • The conference focused on chromatin, chromosomes, and epigenetics.
  • Key areas included transcription, replication, repair, cell differentiation, and disease.

Framework:

  • The event featured keynote speakers Jessica Tyler and Jennifer Mitchell.
  • Sessions covered nuclear and genomic organization, telomeres, and centromeres.

Implementation:

  • Organized by leading scientists from various universities.
  • Held at Asilomar Conference Grounds, Pacific Grove, California.

Implications:

  • Fostered discussion and presentation of research by established scientists and trainees.
  • Highlighted the interdisciplinary nature of chromatin and epigenetics research.