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Researchers identified bacterial nucleotidyltransferases (CD-NTases) that synthesize cyclic dinucleotides and trinucleotides. These enzymes are widespread in bacteria, impacting bacterial functions and host immunity.

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Area of Science:

  • Microbiology
  • Biochemistry
  • Immunology

Background:

  • Bacterial nucleotidyltransferases (CD-NTases) are enzymes involved in synthesizing cyclic nucleotides.
  • These enzymes are crucial for bacterial physiology and host-pathogen interactions.

Purpose of the Study:

  • To define a family of bacterial nucleotidyltransferases (CD-NTases).
  • To investigate the roles of CD-NTases in bacterial physiology and innate immunity.

Main Methods:

  • Bioinformatic analysis to identify CD-NTase sequences across bacterial phyla.
  • Functional characterization of identified CD-NTases (details not provided in abstract).

Main Results:

  • A novel family of CD-NTases was defined, capable of synthesizing pyrimidine-containing cyclic dinucleotides and cyclic trinucleotides.
  • CD-NTases are broadly distributed across diverse bacterial phyla.

Conclusions:

  • The widespread distribution of CD-NTases suggests significant roles in bacterial life.
  • CD-NTases likely play a role in modulating the innate immune system of metazoan hosts.