Management of orbital rhabdomyosarcoma in a child with Li-Fraumeni syndrome
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Updated: Jan 26, 2026

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
Published on: June 13, 2018
Imran Jivraj1, Gino R Somers2, Michel J Belliveau3
1Department of Ophthalmology, The Hospital for Sick Children, Toronto, Ontario.
Abstract:
This case highlights the management of orbital rhabdomyosarcoma in a child with Li Fraumeni syndrome (LFS). Treatment with chemotherapy and eventual orbital exenteration enabled margin-free control of the tumor. Radiation therapy was avoided to reduce the risk of inducing additional malignancy. Reactive orbital hyperostosis was observed postoperatively and was confirmed with surgical biopsy of the orbital roof. In this case, systemic surveillance imaging, which is necessary in patients with LFS, revealed an adrenal cortical carcinoma.
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