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Mean platelet volume and central retinal vein occlusion in hypertensive patients

Pritam Bawankar1, Preetam Samant1, Tatyarao Lahane2

  • 1Department of Vitreo-Retina Surgery, Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, India.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|April 13, 2019
PubMed

Insights

Elevated mean platelet volume (MPV) is linked to central retinal vein occlusion (CRVO) in hypertensive patients. This finding suggests higher MPV may play a role in CRVO development.

Area of Science:

  • Ophthalmology
  • Hematology
  • Cardiology

Background:

  • Hypertension is a significant risk factor for various vascular diseases, including those affecting the retina.
  • Central Retinal Vein Occlusion (CRVO) is a serious ocular condition that can lead to vision loss.
  • Platelets play a crucial role in hemostasis and thrombosis, and their volume may indicate activation state.

Purpose of the Study:

  • To investigate the association between mean platelet volume (MPV) and the occurrence of central retinal vein occlusion (CRVO).
  • To determine if MPV levels differ between hypertensive patients with CRVO and those without.

Main Methods:

  • A retrospective case-control study was conducted with 100 hypertensive patients diagnosed with CRVO and 100 age/sex-matched hypertensive controls.
  • Ocular examinations were performed, and parameters including MPV, platelet count, hemoglobin, white blood cell count, and hematocrit were recorded.
  • Statistical analysis was performed using a 95% confidence interval and a P-value of < 0.05.

Main Results:

  • Mean platelet volume (MPV) was significantly higher in hypertensive patients with CRVO compared to the control group (8.059 ± 0.016 fL vs. 7.442 ± 0.15 fL, P < 0.001).
  • Systolic blood pressure was also significantly higher in the CRVO group.
  • Platelet count differences between groups were not statistically significant.

Conclusions:

  • Increased mean platelet volume (MPV) is significantly associated with central retinal vein occlusion (CRVO) in hypertensive individuals.
  • Higher MPV may be a contributing factor in the pathogenesis of CRVO.
  • MPV could serve as a potential biomarker for CRVO risk assessment in hypertensive patients.
Abstract

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