Related Experiment Video

Updated: Jan 26, 2026

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.3K

The clinical significance of plasma CFHR 1-5 in lupus nephropathy

Xiaofang Hu1, Hengdao Liu2, Jie Du1

  • 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders (Xiangya), Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Immunobiology
|April 13, 2019
PubMed

Insights

Elevated levels of complement factor H-related proteins 3 and 5 (CFHR3 and CFHR5) are linked to lupus nephritis severity. Higher CFHR3 and CFHR5 indicate worse disease activity and poorer prognosis in lupus nephritis patients.

Area of Science:

  • Immunology
  • Nephrology
  • Complement System Biology

Background:

  • Lupus nephritis is characterized by complement factor H deficiency, leading to C3 consumption and C3b deposition.
  • The role of complement factor H-related proteins (CFHRs 1-5) in lupus nephritis pathogenesis is not well understood.
  • Investigating CFHRs may reveal new insights into lupus nephritis development and progression.

Purpose of the Study:

  • To compare circulating levels of CFHR1-5 in lupus nephritis patients versus healthy individuals.
  • To explore the association between CFHR1-5 expression and lupus nephritis disease activity and progression.
  • To evaluate the prognostic value of CFHR3 and CFHR5 in lupus nephritis.

Main Methods:

  • Plasma levels of CFHR1-5 were measured in 152 lupus nephritis patients and 20 healthy controls.
  • Correlations were assessed between CFHR levels, disease activity (SLEDAI), proteinuria, creatinine, C3, and eGFR.
  • Receiver operating characteristic (ROC) curve analysis was used to determine predictive values for disease activity and endpoints.

Main Results:

  • Plasma CFHR3 and CFHR5 levels were significantly higher in lupus nephritis patients compared to controls.
  • CFHR3 and CFHR5 concentrations positively correlated with SLEDAI, proteinuria, creatinine, and anti-dsDNA levels.
  • CFHR3 and CFHR5 levels negatively correlated with C3 levels and eGFR, and were predictive of disease activity and outcomes.

Conclusions:

  • Elevated plasma CFHR3 and CFHR5 are associated with increased disease activity and severity in lupus nephritis.
  • CFHR3 and CFHR5 demonstrate prognostic value, with high levels indicating a worse prognosis and shorter progression-free survival.
  • CFHR3 and CFHR5 may serve as potential biomarkers for monitoring lupus nephritis activity and predicting disease progression.

Keywords:
Complement factor H-related proteinLupus nephritisPrognosis

More Related Videos

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

7.1K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

597

Related Concept Videos

Statistical Significance01:50

Statistical Significance

Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
21.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.3K
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
41.2K
Significance of Center of Mass01:12

Significance of Center of Mass

The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.6K
Significance Testing: Overview01:04

Significance Testing: Overview

Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
11.6K
Significance of Displacement Current01:27

Significance of Displacement Current

A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
5.8K