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Updated: Jan 26, 2026

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Published on: October 14, 2022
Increased Water Content in Periventricular Caps in Patients without Acute Hydrocephalus
T Sichtermann1, J K Furtmann2, S Dekeyzer2,3
1From the Departments of Diagnostic and Interventional Neuroradiology (T.S., J.K.F., S.D., G.G., M.W., O.N.) tsichtermann@ukaachen.de.
Periventricular caps show higher water content than white matter lesions on MR imaging. Quantitative water mapping can differentiate these findings, aiding in characterizing T2-hyperintense diseases.
Area of Science:
- Neuroimaging
- Radiology
- White Matter Diseases
Background:
- Periventricular caps are common MR findings.
- They are thought to result from increased interstitial water due to transependymal transport dysfunction.
Purpose of the Study:
- To compare quantitative water content between periventricular caps and white matter lesions.
- To determine if water content measurement can differentiate these entities.
Main Methods:
- A prospective study involved 50 patients.
- Quantitative multiple-echo, gradient-echo MR imaging water-mapping was used.
Main Results:
- Periventricular caps had significantly higher water content than white matter lesions (P = .002).
- Periventricular caps showed 17% ± 5% higher water content than normal white matter; white matter lesions showed 11% ± 4% higher.
- Water content >15% higher than normal white matter differentiated periventricular caps with 93% specificity and 60% sensitivity (P < .001).
Conclusions:
- Quantitative MR imaging effectively differentiates periventricular caps from white matter lesions.
- Water content quantification is a valuable tool for characterizing T2-hyperintense lesions.
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