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The mevalonate coordinates energy input and cell proliferation

Li Gong1, Yi Xiao1, Fan Xia1,2,3

  • 1Department of Cardiology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, China.

Cell Death & Disease
|April 13, 2019
PubMed

Insights

The mevalonate pathway regulates colon cancer growth by controlling cell proliferation and nutrient uptake. Inhibiting this pathway reduces cancer cell growth and energy consumption.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • The mevalonate pathway is crucial for cholesterol synthesis.
  • Emerging evidence links the mevalonate pathway to Hippo signaling, impacting organ size and tumorigenesis.

Purpose of the Study:

  • To investigate the role of the mevalonate pathway in colon cancer cell proliferation and energy metabolism.
  • To determine if mevalonate pathway inhibition affects nutrient uptake in colon cancer.

Main Methods:

  • Transcriptomic and proteomic analyses to identify controlled signaling pathways.
  • Western blot, PCR, and immunofluorescence assays for validation.
  • Assays to measure glucose and amino acid uptake and lactate production.

Main Results:

  • Suppression of the mevalonate pathway inhibits colon cancer cell growth and proliferation.
  • The mevalonate pathway regulates multiple cell proliferation signaling pathways.
  • Inhibitors like lovastatin reduce glucose and amino acid uptake and lactate production.
  • Mevalonic acid promotes glucose uptake in colon cancer cells.
  • Colon cancer tissues show elevated mevalonate pathway enzyme expression.

Conclusions:

  • The mevalonate pathway is a critical regulator of colon cancer cell proliferation.
  • This pathway coordinates energy supply with cell proliferation by controlling nutrient uptake.
  • Targeting the mevalonate pathway presents a potential therapeutic strategy for colon cancer.

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